This drama is about the pride and frustration of cardiac surgeons on the job. Lee Eun Sung (Ji Sung) graduated from a newly established medical school in the southern province and not from an elite one like the Kwang Hee University Hospital where he applied for residency with the hope of becoming a great cardiac specialist. Since he wasn't a graduate of Kwang Hee Uni., he was looked down upon by almost everyone at the hospital.
Nam Hye Suk (Kim Min Jung) graduated with top marks and was regarded as a star student. She was an absolute fundamentalist and proud of herself. Dr. Choi Kang Gook (Jo Jae Hyun) became the new head of the Department of Thoracic and Cardiovascular Surgery after being in exile for 5 years for getting into trouble with his former superior. He was a genius but he was also a stubborn surgeon who does not care for hospital politics.